New
findings show that eating a high-fat diet beginning at puberty speeds
up the development of breast cancer and may actually increase the risk
of cancer similar to a type often found in younger adult women.
The research comes from the Breast Cancer and the Environment
Research Program at Michigan State University and is published in the
current online issue of
Breast Cancer Research.
Utilizing a preclinical model, the findings indicate that before any
tumors appear, there are changes in the breast that include increased
cell growth and alterations in immune cells. These changes persist into
adulthood and can lead to the rapid development of precancerous lesions
and ultimately breast cancer.
In addition to the accelerated breast cancer development, this type
of diet produces a distinct gene signature in the tumors consistent with
a subset of breast cancers known as basal-like that can carry a worse
prognosis.
“This is very significant because even though the cancers arise from
random mutations, the gene signature indicating a basal-like breast
cancer shows the overarching and potent influence this type of diet has
in the breast,” said Sandra Haslam, physiology professor in MSU’s
College of Human Medicine and one of the lead investigators of the
project.
“Cancers of this type are more aggressive in nature and typically
occur in younger women. This highlights the significance of our work
toward efforts against the disease.”
Richard Schwartz, microbiology professor and associate dean in the
College of Natural Science, has co-led research efforts with Haslam
since 2010. The research is funded by a five-year, $2.3 million federal
grant from the National Institute of Environmental Health Sciences and
the National Cancer Institute.
“It’s important to note that since our experimental model did not
involve any weight gain from the high-fat diet, these findings are
relevant to a much broader segment of the population than just those who
are overweight,” said Schwartz. “This shows the culprit is the fat
itself rather than weight gain.”
Early evidence indicates that the fat, which in this case was
saturated animal fat, could potentially have permanent effects even if a
low-fat diet is introduced later in life. Schwartz cautions, however,
that this preliminary finding requires further investigation and doesn’t
indicate with certainty that humans will be affected in the same way.
“Overall, our current research indicates that avoiding excessive
dietary fat of this type may help lower one’s risk of breast cancer down
the road,” he said. “And since there isn’t any evidence suggesting that
avoiding this type of diet is harmful, it just makes sense to do it.”
The research project is part of a consortium, the national Breast
Cancer and the Environment Research Program, which studies the impact of
prenatal-to-adult environmental exposures that predispose women to
breast cancer.
Besides performing biomedical research, the project also strives to
communicate findings that can lessen the risk of breast cancer through
awareness and avoidance of environmental risk factors. Haslam and
Schwartz have partnered with the Michigan Breast Cancer Coalition and
professors Kami Silk and Sandi Smith in MSU's College of Communication
Arts and Sciences to bring these research findings to the public.
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http://msutoday.msu.edu/news/2013/high-fat-diet-during-puberty-speeds-up-breast-cancer-development/#sthash.l3Kxu7LE.dpuf
New findings show that eating a
high-fat diet beginning at puberty speeds up the development of breast cancer
and may actually increase the risk of cancer similar to a type often found in
younger adult women.
The research comes from the Breast
Cancer and the Environment Research Program at Michigan State University and is
published in the current online issue of Breast Cancer Research.
Utilizing a preclinical model, the
findings indicate that before any tumors appear, there are changes in the
breast that include increased cell growth and alterations in immune cells.
These changes persist into adulthood and can lead to the rapid development of
precancerous lesions and ultimately breast cancer.
In addition to the accelerated
breast cancer development, this type of diet produces a distinct gene signature
in the tumors consistent with a subset of breast cancers known as basal-like
that can carry a worse prognosis.
“This is very significant because
even though the cancers arise from random mutations, the gene signature
indicating a basal-like breast cancer shows the overarching and potent
influence this type of diet has in the breast,” said Sandra Haslam, physiology
professor in MSU’s College of Human Medicine and one of the lead investigators
of the project.
“Cancers of this type are more
aggressive in nature and typically occur in younger women. This highlights the
significance of our work toward efforts against the disease.”
Richard Schwartz, microbiology
professor and associate dean in the College of Natural Science, has co-led
research efforts with Haslam since 2010. The research is funded by a five-year,
$2.3 million federal grant from the National Institute of Environmental Health
Sciences and the National Cancer Institute.
“It’s important to note that since
our experimental model did not involve any weight gain from the high-fat diet,
these findings are relevant to a much broader segment of the population than
just those who are overweight,” said Schwartz. “This shows the culprit is the
fat itself rather than weight gain.”
Early evidence indicates that the
fat, which in this case was saturated animal fat, could potentially have
permanent effects even if a low-fat diet is introduced later in life. Schwartz
cautions, however, that this preliminary finding requires further investigation
and doesn’t indicate with certainty that humans will be affected in the same
way.
“Overall, our current research
indicates that avoiding excessive dietary fat of this type may help lower one’s
risk of breast cancer down the road,” he said. “And since there isn’t any
evidence suggesting that avoiding this type of diet is harmful, it just makes
sense to do it.”
The research project is part of a
consortium, the national Breast Cancer and the Environment Research Program,
which studies the impact of prenatal-to-adult environmental exposures that
predispose women to breast cancer.
Besides performing biomedical
research, the project also strives to communicate findings that can lessen the
risk of breast cancer through awareness and avoidance of environmental risk
factors. Haslam and Schwartz have partnered with the Michigan Breast Cancer
Coalition and professors Kami Silk and Sandi Smith in MSU's College of
Communication Arts and Sciences to bring these research findings to the public.
New findings show that eating a
high-fat diet beginning at puberty speeds up the development of breast cancer
and may actually increase the risk of cancer similar to a type often found in
younger adult women.
The research comes from the Breast
Cancer and the Environment Research Program at Michigan State University and is
published in the current online issue of Breast Cancer Research.
Utilizing a preclinical model, the
findings indicate that before any tumors appear, there are changes in the
breast that include increased cell growth and alterations in immune cells.
These changes persist into adulthood and can lead to the rapid development of
precancerous lesions and ultimately breast cancer.
In addition to the accelerated
breast cancer development, this type of diet produces a distinct gene signature
in the tumors consistent with a subset of breast cancers known as basal-like
that can carry a worse prognosis.
“This is very significant because
even though the cancers arise from random mutations, the gene signature
indicating a basal-like breast cancer shows the overarching and potent
influence this type of diet has in the breast,” said Sandra Haslam, physiology
professor in MSU’s College of Human Medicine and one of the lead investigators
of the project.
“Cancers of this type are more
aggressive in nature and typically occur in younger women. This highlights the
significance of our work toward efforts against the disease.”
Richard Schwartz, microbiology
professor and associate dean in the College of Natural Science, has co-led
research efforts with Haslam since 2010. The research is funded by a five-year,
$2.3 million federal grant from the National Institute of Environmental Health
Sciences and the National Cancer Institute.
“It’s important to note that since
our experimental model did not involve any weight gain from the high-fat diet,
these findings are relevant to a much broader segment of the population than
just those who are overweight,” said Schwartz. “This shows the culprit is the
fat itself rather than weight gain.”
Early evidence indicates that the
fat, which in this case was saturated animal fat, could potentially have
permanent effects even if a low-fat diet is introduced later in life. Schwartz
cautions, however, that this preliminary finding requires further investigation
and doesn’t indicate with certainty that humans will be affected in the same
way.
“Overall, our current research
indicates that avoiding excessive dietary fat of this type may help lower one’s
risk of breast cancer down the road,” he said. “And since there isn’t any
evidence suggesting that avoiding this type of diet is harmful, it just makes
sense to do it.”
The research project is part of a
consortium, the national Breast Cancer and the Environment Research Program,
which studies the impact of prenatal-to-adult environmental exposures that
predispose women to breast cancer.
Besides performing biomedical
research, the project also strives to communicate findings that can lessen the
risk of breast cancer through awareness and avoidance of environmental risk
factors. Haslam and Schwartz have partnered with the Michigan Breast Cancer
Coalition and professors Kami Silk and Sandi Smith in MSU's College of
Communication Arts and Sciences to bring these research findings to the public.
New findings show that eating a
high-fat diet beginning at puberty speeds up the development of breast cancer
and may actually increase the risk of cancer similar to a type often found in
younger adult women.
The research comes from the Breast
Cancer and the Environment Research Program at Michigan State University and is
published in the current online issue of Breast Cancer Research.
Utilizing a preclinical model, the
findings indicate that before any tumors appear, there are changes in the
breast that include increased cell growth and alterations in immune cells.
These changes persist into adulthood and can lead to the rapid development of
precancerous lesions and ultimately breast cancer.
In addition to the accelerated
breast cancer development, this type of diet produces a distinct gene signature
in the tumors consistent with a subset of breast cancers known as basal-like
that can carry a worse prognosis.
“This is very significant because
even though the cancers arise from random mutations, the gene signature
indicating a basal-like breast cancer shows the overarching and potent
influence this type of diet has in the breast,” said Sandra Haslam, physiology
professor in MSU’s College of Human Medicine and one of the lead investigators
of the project.
“Cancers of this type are more
aggressive in nature and typically occur in younger women. This highlights the
significance of our work toward efforts against the disease.”
Richard Schwartz, microbiology
professor and associate dean in the College of Natural Science, has co-led
research efforts with Haslam since 2010. The research is funded by a five-year,
$2.3 million federal grant from the National Institute of Environmental Health
Sciences and the National Cancer Institute.
“It’s important to note that since
our experimental model did not involve any weight gain from the high-fat diet,
these findings are relevant to a much broader segment of the population than
just those who are overweight,” said Schwartz. “This shows the culprit is the
fat itself rather than weight gain.”
Early evidence indicates that the
fat, which in this case was saturated animal fat, could potentially have
permanent effects even if a low-fat diet is introduced later in life. Schwartz
cautions, however, that this preliminary finding requires further investigation
and doesn’t indicate with certainty that humans will be affected in the same
way.
“Overall, our current research
indicates that avoiding excessive dietary fat of this type may help lower one’s
risk of breast cancer down the road,” he said. “And since there isn’t any
evidence suggesting that avoiding this type of diet is harmful, it just makes
sense to do it.”
The research project is part of a
consortium, the national Breast Cancer and the Environment Research Program,
which studies the impact of prenatal-to-adult environmental exposures that
predispose women to breast cancer.
Besides performing biomedical
research, the project also strives to communicate findings that can lessen the
risk of breast cancer through awareness and avoidance of environmental risk
factors. Haslam and Schwartz have partnered with the Michigan Breast Cancer
Coalition and professors Kami Silk and Sandi Smith in MSU's College of
Communication Arts and Sciences to bring these research findings to the public.