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Monday, 7 October 2013

Boston University Researchers Test Effectiveness of Behavioral and Medication Treatments for Patients with Alcoholism and Anxiety

Domenic Ciraulo, MDDomenic Ciraulo, MD, chair of psychiatry at Boston University School of Medicine (BUSM) and David H. Barlow, PhD, professor of psychology at Boston University (BU), have collaborated to study the effect of behavioral and medication treatments on patients with alcoholism and anxiety.
The findings, published in the journal Behaviour Research and Therapy, suggest that Transdiagnostic cognitive behavioral therapy (CBT) was more effective in reducing heavy drinking in anxious alcoholics than progressive muscle relaxation therapy (PMR). They also found that the addition of medication to either CBT or PMR participants did not decrease their alcohol consumption.
Participants were divided into four groups; one receiving the antidepressant Venlaflaxine coupled with CBT, one receiving Venlaflaxine with PMR, and the other groups receiving a placebo coupled with either CBT or PMR. After 11 weeks the participants in the group receiving a placebo and CBT alone reported their heavy drinking had significantly decreased when compared to the other groups receiving treatment.
“It is vital to find better treatments, whether they are medication therapies or behavioral interventions,” said Ciraulo, principal investigator of the study. “This study points to the importance of behavioral approaches to decrease heavy drinking through strategies to improve emotional regulation.”
David H. Barlow, PhDAccording to the researchers, while anti-depressant medications may help to control anxious feelings, the ability to acknowledge and respond to such intense feelings may be one reason that CBT is effective. This may be why the addition of an anti-depressant to CBT did not lead to improved outcomes.
David H. Barlow, PhD
“The goal of Transdiagnostic CBT in this study was not to directly treat the specific anxiety  symptoms of each anxiety disorder, but rather teach broad skills to cope with emotional issues that underlie a cluster of internalizing (mood and anxiety) disorders that often accompany alcoholism and may contribute to its onset and maintenance,” said Barlow co-author of the study.
Source:Boston University

Sunday, 6 October 2013

Biomarker for Pancreatic Cancer Discovered

Phosphatidylserine (PS) biomarker for pancreatic cancer has been identified by scientists.
 These findings, being published in the Oct. 4, 2013, online edition of PLOS ONE, also show that the use of a biotherapy consisting of lysosomal protein, known as saposin C (SapC), and a phospholipid, known as dioleoylphosphatidylserine (DOPS), can be combined into tiny cavities, or nanovesicles, to target and kill pancreatic cancer cells. Lysosomes are membrane-enclosed organelles that contain enzymes capable of breaking down all types of biological components; phospholipids are a major components of all cell membranes and form lipid bilayers—or cell membranes. "Only a small number of promising drugs target pancreatic cancer, which is the fourth-leading cause of cancer deaths, with a five-year survival of less than 5 percent," says Xiaoyang Qi, PhD, associate professor of hematology oncology at UC and lead researcher on the study. "Pancreatic cancer is usually asymptomatic in the early stages, while frequently invading lymph nodes and the liver, and less often the lungs and visceral organs. Current treatments, including surgery, chemotherapy and radiation therapy, have failed to improve long-term survival." Qi says his lab and collaborators previously found that the combination of two natural cellular components, called SapC-DOPS, which were assembled and delivered using cancer-selective nanovesicles, caused cell death in other cancer cell types, including brain, lung, skin, prostate, blood and breast cancer, while sparing normal cells and tissues. "We also investigated the efficacy and systemic biodistribution of SapC-DOPS nanovesicles in animal models and found that it targeted and halted growth of certain cancer cells and showed no toxic effects in non-tumor tissues. In this study, we selectively targeted the cell membrane of pancreatic tumors to see if we could destroy malignant pancreatic cells without harming normal tissues and cells." Qi says a distinguishing feature of SapC-DOPS is its ability to bind to phosphatidylseriine (PS), a lipid, which is found on the membrane surfaces of pancreatic tumor cells. "To evaluate the role of external cell PS, we used PS exposure in human tumor and non-tumor cells via culture," he says. "We also introduced these cells into animal models and then injected the SapC-DOPS vesicles to see if changes were observed. " In some portions of the experiment, the SapC-DOPS nanovesicles were fluorescently labeled with a dye which could be followed using an imaging device. To track tumor cells, human pancreatic tumor cells were illuminated with dye as well, and the same imaging device was used to identify and monitor them. "We observed that the nanovesicles selectively killed human pancreatic cancer cells, and the noncancerous, or untransformed cells, remained unaffected," he says. "This toxic effect correlated to the surface exposure level of PS on the tumor cells." Qi adds that animals treated with SapC-DOPS showed clear survival benefits and their tumors shrank or disappeared. "Furthermore, using a double-tracking method in live models, we showed that the nanovesicles were specifically targeted to the tumors," he says. "These data suggest that the acidic phospholipid PS is a biomarker for pancreatic cancer that can be effectively targeted for therapy using cancer-selective SapC-DOPS nanovesicles. "This study provides convincing evidence in support of developing a new therapeutic approach to pancreatic cancer. This technology is now being licensed and will hopefully be available in clinical trials soon." "Dr. Qi 's discovery has great potential to be developed into diagnostics and therapies for pancreatic cancer," says Shuk-mei Ho, PhD, director of the Cincinnati Cancer Center and Jacob G. Schmidlapp Professor and Chair of Environmental Health. "This type of research helps fulfill the mission of the National Cancer Institute to promote translation of research from the bench to the bedside."
Source: PLOS ONE

 

Blocking Nerve Cells Could Help Curb Eczema

A new link between the immune and nervous system which lead to itching an inflammation during eczema, a chronic skin disease, may help develop new remedies for the disease.
 Blocking Nerve Cells Could Help Curb Eczema
Some 10 percent of the population suffers from eczema, or atopic dermatitis, at some point in their lives, but there are no cures or even good treatments for it. Symptoms range from dry, flaky and itchy skin to flaming red rashes, and in severe cases, particularly in children, the disease often progresses to nasal allergies and asthma. Eczema's cause is unknown, but most research today focuses on the immune system's role in reacting to chemicals that cause itching and inflammation. UC Berkeley neuroscientist Diana M. Bautista and graduate students Sarah R. Wilson and Lydia Thé, however, discovered that sensory nerves in the skin are the first to react to these chemicals, and that blocking the skin's itch receptors not only stops the scratching, but may head off the worst consequences of eczema. "Most drug development has focused on trying to find a way to inhibit the immune response," said Bautista, assistant professor of molecular and cell biology and a member of the Helen Wills Neuroscience Institute. "Now that we have found that sensory neurons may be the first responders, that changes how we think about the disease." "By just blocking what is happening in the neurons, you could block the symptoms of chronic itch, including the big immune response leading to asthma and allergy," Wilson added. "And you prevent the patient from scratching, which damages skin cells and makes them release more chemicals that cause inflammation and help maintain chronic itch." The researchers already have identified a potential drug, now in Phase 1 clinical trials for a different inflammatory disease, that stops mice from scratching when it is applied to the skin. Their new model of eczema is based on findings reported online today (Thursday, Oct. 3) in the journal Cell by Bautista, Wilson, Thé and their UC Berkeley colleagues.

Block that wasabi 
"We started out looking at acute itch and asked the question, 'Why do we scratch? Why do we have that urge, and how does it work that scratching gives you some relief, when normally it feels terrible if you don't have an itch and scratch yourself that hard?'" Bautista said. "But the many types of chronic itch that humans experience are all very different. We believe that, through identifying molecular mechanisms, we can find new treatments and therapies for these diseases." Immunologists several years ago identified a chemical - TSLP (thymic stromal lymphopoietin), a so-called cytokine - that induces itch when expressed in the skin. Because immune cells have receptors for this chemical, TSLP triggers them to release chemicals that attract other immune cells and to create the red, itchy inflammation typical of eczema. These inflammatory chemicals seem to spread through the body and induce inflammation in the lungs, gut and nasal passages that lead to asthma and allergies, Bautista said. Wilson and Bautista, however, focused on what causes the immediate or acute itch. Probing itch-sensitive neurons in the skin, they found that these neurons also have receptors for TSLP, and that TSLP makes these neurons, like immune cells, release chemical mediators that cause inflammation. Furthermore, by looking at human skin cells (keratinocytes) in culture, they discovered the triggers that make skin cells release TSLP in the first place. "Our hypothesis is that skin cells release TSLP, which triggers neurons to release mediators that lead to more inflammation and recruitment of immune cells," helping to set up chronic inflammation, Bautista said. "These itch-sensitive neurons are a small population," she added. "If we could just block the 2 percent of neurons that respond to TSLP, we could have a really selective drug that treats chronic itch, but keeps all of the important functions of skin - normal pain function, normal temperature and tactile sensations - and the many parts of the immune system intact." Interestingly, the TSLP receptor works through an ion channel, TRPA1, that Bautista discovered when she was a post-doctoral researcher. The channel was named the wasabi ion channel because it is sensitive to "mustard compounds" like those found in Dijon or wasabi. Blockers of the wasabi channel thus would block the action of TSLP and stop itch. Alternatively, Wilson said, drug developers could look for chemicals that block the release of TSLP from damaged skin cells. Bautista and her colleagues are continuing to explore the relative contributions of different types of nerve and immune cells to atopic dermatitis and chronic itch and are developing mouse models in which to test their hypotheses. 
Source:Journal Cell
 

 

One in 16 People Addicted to Sex: Study

 One in 16 People Addicted to Sex: StudyA recent study reveals that one in sixteen people in the UK are addicted to taking part in sexual acts every day. According to some experts, sex addiction is now worse than drugs or booze, the Sun reported.
The study by scientists at Belgium's Liege University found that men are three times likelier than woman to be addicted. They told the publication that compulsive flirting, addiction to porn, phone-sex, sex on the internet, addiction to drugs and toys used for pleasure can be signs of excessive sexuality.
Source-ANI
 
 

10 Easy Things That Will Make You Happier, Backed By Science

 
1. Exercise more – 
7 minutes might be enoughYou might have seen some talk recently about the scientific 7 minute workout mentioned in The New York Times. So if you thought exercise was something you didn’t have time for, maybe you can fit it in after all.Exercise has such a profound effect on our happiness and well-being that it’s actually been proven to be an effective strategy for overcoming depression. In a study cited in Shawn Achor’s book, The Happiness Advantage, three groups of patients treated their depression with either medication, exercise, or a combination of the two. The results of this study really surprised me. Although all three groups experienced similar improvements in their happiness levels to begin with, the follow up assessments proved to be radically different:The groups were then tested six months later to assess their relapse rate. Of those who had taken the medication alone, 38 percent had slipped back into depression. Those in the combination group were doing only slightly better, with a 31 percent relapse rate. The biggest shock, though, came from the exercise group: Their relapse rate was only 9 percent! In NutureShock, Po Bronson and Ashley Merryman explain how sleep affects our positivity:Negative stimuli get processed by the amygdala; positive or neutral memories gets processed by the hippocampus. Sleep deprivation hits the hippocampus harder than the amygdala. The result is that sleep-deprived people fail to recall pleasant memories, yet recall gloomy memories just fine.In one experiment by Walker, sleep-deprived college students tried to memorize a list of words. They could remember 81% of the words with a negative connotation, like “cancer.” But they could remember only 31% of the words with a positive or neutral connotation, like “sunshine” or “basket.”The BPS Research Digest explores another study that proves sleep affects our sensitivity to negative emotions. Using a facial recognition task over the course of a day, the researchers studied how sensitive participants were to positive and negative emotions. Those who worked through the afternoon without taking a nap became more sensitive late in the day to negative emotions like fear and anger. Using a face recognition task, here we demonstrate an amplified reactivity to anger and fear emotions across the day, without sleep. However, an intervening nap blocked and even reversed this negative emotional reactivity to anger and fear while conversely enhancing ratings of positive (happy) expressions. Of course, how well (and how long) you sleep will probably affect how you feel when you wake up, which can make a difference to your whole day. Especially this graph showing how your brain activity decreases is a great insight about how important enough sleep is for productivity and happiness: You don’t have to be depressed to gain benefit from exercise, though. It can help you to relax, increase your brain power and even improve your body image, even if you don’t lose any weight.A study in the Journal of Health Psychology found that people who exercised felt better about their bodies, even when they saw no physical changes:Body weight, shape and body image were assessed in 16 males and 18 females before and after both 6 × 40 mins exercise and 6 × 40 mins reading. Over both conditions, body weight and shape did not change. Various aspects of body image, however, improved after exercise compared to before. We’ve explored exercise in depth before, and looked at what it does to our brains, such as releasing proteins and endorphins that make us feel happier, as you can see in the image below. 
2. Sleep more – you’ll be less sensitive to negative emotionsWe know that sleep helps our bodies to recover from the day and repair themselves, and that it helps us focus and be more productive. It turns out, it’s also important for our happiness. Another study tested how employees’ moods when they started work in the morning affected their work day.Researchers found that employees’ moods when they clocked in tended to affect how they felt the rest of the day. Early mood was linked to their perceptions of customers and to how they reacted to customers’ moods. And most importantly to managers, employee mood had a clear impact on performance, including both how much work employees did and how well they did it.Sleep is another topic we’ve looked into before, exploring how much sleep we really need to be productive. 
3. Move closer to work – a short commute is worth more than a big houseOur commute to the office can have a surprisingly powerful impact on our happiness. The fact that we tend to do this twice a day, five days a week, makes it unsurprising that its effect would build up over time and make us less and less happy.According to The Art of Manliness, having a long commute is something we often fail to realize will affect us so dramatically:… while many voluntary conditions don’t affect our happiness in the long term because we acclimate to them, people never get accustomed to their daily slog to work because sometimes the traffic is awful and sometimes it’s not. Or as Harvard psychologist Daniel Gilbert put it, “Driving in traffic is a different kind of hell every day.” We tend to try to compensate for this by having a bigger house or a better job, but these compensations just don’t work:Two Swiss economists who studied the effect of commuting on happiness found that such factors could not make up for the misery created by a long commute. 
4. Spend time with friends and family – don’t regret it on your deathbedStaying in touch with friends and family is one of the top five regrets of the dying. If you want more evidence that it’s beneficial for you, I’ve found some research that proves it can make you happier right now.Social time is highly valuable when it comes to improving our happiness, even for introverts. Several studies have found that time spent with friends and family makes a big difference to how happy we feel, generally.I love the way Harvard happiness expert Daniel Gilbert explains it:We are happy when we have family, we are happy when we have friends and almost all the other things we think make us happy are actually just ways of getting more family and friends. George Vaillant is the director of a 72-year study of the lives of 268 men.In an interview in the March 2008 newsletter to the Grant Study subjects, Vaillant was asked, “What have you learned from the Grant Study men?” Vaillant’s response: “That the only thing that really matters in life are your relationships to other people.” He shared insights of the study with Joshua Wolf Shenk at The Atlantic on how the men’s social connections made a difference to their overall happiness:The men’s relationships at age 47, he found, predicted late-life adjustment better than any other variable, except defenses. Good sibling relationships seem especially powerful: 93 percent of the men who were thriving at age 65 had been close to a brother or sister when younger. In fact, a study published in the Journal of Socio-Economics states than your relationships are worth more than $100,000:Using the British Household Panel Survey, I find that an increase in the level of social involvements is worth up to an extra £85,000 a year in terms of life satisfaction. Actual changes in income, on the other hand, buy very little happiness. I think that last line is especially fascinating: Actual changes in income, on the other hand, buy very little happiness. So we could increase our annual income by hundreds of thousands of dollars and still not be as happy as if we increased the strength of our social relationships.The Terman study, which is covered in The Longevity Project, found that relationships and how we help others were important factors in living long, happy lives:We figured that if a Terman participant sincerely felt that he or she had friends and relatives to count on when having a hard time then that person would be healthier. Those who felt very loved and cared for, we predicted, would live the longest. Surprise: our prediction was wrong… Beyond social network size, the clearest benefit of social relationships came from helping others. Those who helped their friends and neighbors, advising and caring for others, tended to live to old age. 
5. Go outside – happiness is maximized at 13.9°CIn The Happiness Advantage, Shawn Achor recommends spending time in the fresh air to improve your happiness:Making time to go outside on a nice day also delivers a huge advantage; one study found that spending 20 minutes outside in good weather not only boosted positive mood, but broadened thinking and improved working memory… This is pretty good news for those of us who are worried about fitting new habits into our already-busy schedules. Twenty minutes is a short enough time to spend outside that you could fit it into your commute or even your lunch break.A UK study from the University of Sussex also found that being outdoors made people happier:Being outdoors, near the sea, on a warm, sunny weekend afternoon is the perfect spot for most. In fact, participants were found to be substantially happier outdoors in all natural environments than they were in urban environments. The American Meteorological Society published research in 2011 that found current temperature has a bigger effect on our happiness than variables like wind speed and humidity, or even the average temperature over the course of a day. It also found that happiness is maximized at 13.9°C, so keep an eye on the weather forecast before heading outside for your 20 minutes of fresh air. 
6. Help others – 100 hours a year is the magical numberOne of the most counterintuitive pieces of advice I found is that to make yourself feel happier, you should help others. In fact, 100 hours per year (or two hours per week) is the optimal time we should dedicate to helping others in order to enrich our lives.If we go back to Shawn Achor’s book again, he says this about helping others:…when researchers interviewed more than 150 people about their recent purchases, they found that money spent on activities—such as concerts and group dinners out—brought far more pleasure than material purchases like shoes, televisions, or expensive watches. Spending money on other people, called “prosocial spending,” also boosts happiness. The Journal of Happiness Studies published a study that explored this very topic:Participants recalled a previous purchase made for either themselves or someone else and then reported their happiness. Afterward, participants chose whether to spend a monetary windfall on themselves or someone else. Participants assigned to recall a purchase made for someone else reported feeling significantly happier immediately after this recollection; most importantly, the happier participants felt, the more likely they were to choose to spend a windfall on someone else in the near future. So spending money on other people makes us happier than buying stuff for ourselves. What about spending our time on other people? A study of volunteering in Germany explored how volunteers were affected when their opportunities to help others were taken away:Shortly after the fall of the Berlin Wall but before the German reunion, the first wave of data of the GSOEP was collected in East Germany. Volunteering was still widespread. Due to the shock of the reunion, a large portion of the infrastructure of volunteering (e.g. sports clubs associated with firms) collapsed and people randomly lost their opportunities for volunteering. Based on a comparison of the change in subjective well-being of these people and of people from the control group who had no change in their volunteer status, the hypothesis is supported that volunteering is rewarding in terms of higher life satisfaction. In his book Flourish: A Visionary New Understanding of Happiness and Well-being, University of Pennsylvania professor Martin Seligman explains that helping others can improve our own lives:…we scientists have found that doing a kindness produces the single most reliable momentary increase in well-being of any exercise we have tested.  
7. Practice smiling – it can alleviate painSmiling itself can make us feel better, but it’s more effective when we back it up with positive thoughts, according to this study:A new study led by a Michigan State University business scholar suggests customer-service workers who fake smile throughout the day worsen their mood and withdraw from work, affecting productivity. But workers who smile as a result of cultivating positive thoughts – such as a tropical vacation or a child’s recital – improve their mood and withdraw less. Of course it’s important to practice “real smiles” where you use your eye sockets. It’s very easy to spot the difference:According to PsyBlog, smiling can improve our attention and help us perform better on cognitive tasks: Smiling makes us feel good which also increases our attentional flexibility and our ability to think holistically. When this idea was tested by Johnson et al. (2010), the results showed that participants who smiled performed better on attentional tasks which required seeing the whole forest rather than just the trees. A smile is also a good way to alleviate some of the pain we feel in troubling circumstances:Smiling is one way to reduce the distress caused by an upsetting situation. Psychologists call this the facial feedback hypothesis. Even forcing a smile when we don’t feel like it is enough to lift our mood slightly (this is one example of embodied cognition). One of our previous posts goes into even more detail about the science of smiling. 
8. Plan a trip – but don’t take oneAs opposed to actually taking a holiday, it seems that planning a vacation or just a break from work can improve our happiness. A study published in the journal, Applied Research in Quality of Lifeshowed that the highest spike in happiness came during the planning stage of a vacation as employees enjoyed the sense of anticipation:In the study, the effect of vacation anticipation boosted happiness for eight weeks.After the vacation, happiness quickly dropped back to baseline levels for most people.Shawn Achor has some info for us on this point, as well:One study found that people who just thought about watching their favorite movie actually raised their endorphin levels by 27 percent.If you can’t take the time for a vacation right now, or even a night out with friends, put something on the calendar—even if it’s a month or a year down the road. Then whenever you need a boost of happiness, remind yourself about it. 
9. Meditate – rewire your brain for happinessMeditation is often touted as an important habit for improving focus, clarity and attention span, as well as helping to keep you calm. It turns out it’s also useful for improving your happiness:In one study, a research team from Massachusetts General Hospital looked at the brain scans of 16 people before and after they participated in an eight-week course in mindfulness meditation. The study, published in the January issue of Psychiatry Research: Neuroimaging, concluded that after completing the course, parts of the participants’ brains associated with compassion and self-awareness grew, and parts associated with stress shrank. Meditation literally clears your mind and calms you down, it’s been often proven to be the single most effective way to live a happier live. I believe that this graphic explains it the best:According to Shawn Achor, meditation can actually make you happier long-term: Studies show that in the minutes right after meditating, we experience feelings of calm and contentment, as well as heightened awareness and empathy. And, research even shows that regular meditation can permanently rewire the brain to raise levels of happiness.The fact that we can actually alter our brain structure through mediation is most surprising to me and somewhat reassuring that however we feel and think today isn’t permanent. 
10. Practice gratitude – increase both happiness and life satisfactionThis is a seemingly simple strategy, but I’ve personally found it to make a huge difference to my outlook. There are lots of ways to practice gratitude, from keeping a journal of things you’re grateful for, sharing three good things that happen each day with a friend or your partner, and going out of your way to show gratitude when others help you.In an experiment where some participants took note of things they were grateful for each day, their moods were improved just from this simple practice:The gratitude-outlook groups exhibited heightened well-being across several, though not all, of the outcome measures across the 3 studies, relative to the comparison groups. The effect on positive affect appeared to be the most robust finding. Results suggest that a conscious focus on blessings may have emotional and interpersonal benefits. The Journal of Happiness studies published a study that used letters of gratitude to test how being grateful can affect our levels of happiness:Participants included 219 men and women who wrote three letters of gratitude over a 3 week period. Results indicated that writing letters of gratitude increased participants’ happiness and life satisfaction, while decreasing depressive symptoms.Quick last fact: Getting older will make yourself happierAs a final point, it’s interesting to note that as we get older, particularly past middle age, we tend togrow happier naturally. There’s still some debate over why this happens, but scientists have got a few ideas:Researchers, including the authors, have found that older people shown pictures of faces or situations tend to focus on and remember the happier ones more and the negative ones less. Other studies have discovered that as people age, they seek out situations that will lift their moods — for instance, pruning social circles of friends or acquaintances who might bring them down. Still other work finds that older adults learn to let go of loss and disappointment over unachieved goals, and hew their goals toward greater wellbeing.So if you thought being old would make you miserable, rest assured that it’s likely you’ll develop a more positive outlook than you probably have now.
Source:Higher Perspective

How to stay sharp in retirement

Motivation key factor in preserving brainpower later in life, Concordia University researchers show

Montreal, October 1, 2013 – October is Canada's Healthy Workplace Month, but how does one stay mentally fit after the 40-hour workweek is traded in for the gold watch?
The more you want to use your brain — and the more you enjoy doing it — the more likely you are to stay sharp as you age. This is according to findings recently published in the Journals of Gerontology: Psychological Sciences by a team of Concordia University researchers.
The new study has three major findings that can help forecast cognitive ability in one's golden years:
  1. The more one seeks out and enjoys cognitively demanding activities, the less likely one is to experience cognitive decline later in life.
  2. Doing a variety of different cognitive activities helps boost brainpower post-retirement.
  3. People who exhibit even mild signs of depression are more likely to show a decline in brainpower once they leave the office for good.
First author Larry Baer explains that, "retirement usually occurs right around the time when normal age-related declines in cognitive function come to the fore. So it is important to understand what is happening to brainpower during this period and to identify risk factors for mental decline, as well as factors that will help protect against it."
This study has far-reaching implications. Says Baer, "it is my hope that these results will influence the design of future interventions aimed at maintaining the cognitive health of retirees. This can be done by focusing on getting people to intensify their engagement in a variety of cognitive activities even if they have lower levels of motivation to do so. It is equally important to address symptoms of depression to help fight against cognitive decline."
Baer, who is currently a PhD candidate at Concordia, worked with fellow researchers Nassim Tabri, Mervin Blair and Dorothea Bye, under the leadership of senior authors Dolores Pushkar and Karen Li. They used data collected over four years, from 333 recent retirees. Participants, who were an average age of 59 and mostly in good health and free of any serious mobility limitations when the study started, underwent assessments of cognition, motivation and activities once a year.
Source: Concordia University

New study suggests changing bacterial mix may lead to painful sex after menopause

The mix of bacteria in the vagina changes as women go through menopause. And a certain mix is typical after menopause in women who have vulvovaginal atrophy (VVA), a common cause of vaginal dryness and sexual pain, finds a team at Johns Hopkins and the University of Maryland. They suspect these bacteria may play a role in causing VVA and that personalized probiotics or other ways to manage the bacterial mix might prevent or treat VVA in the future. Their study was published online today in Menopause, the journal of The North American Menopause Society.
Lubricants with intercourse or vaginal moisturizers are considered first-line therapies for women with VVA symptoms. And when VVA is moderate to severe, low-dose estrogen in the vagina is the therapeutic standard. But these therapies have drawbacks. Some women, including certain cancer survivors, cannot use vaginal estrogen, and some women don't wish to use hormones. On the other hand, some lubricants or moisturizers may have detrimental effects on the bacterial mix or the vaginal lining or may even increase a woman's susceptibility to infction. So, alternative treatments such as probiotics will certainly be welcome.
Knowing just what bacterial mixes are healthy or unhealthy is the critical first step toward modifying the mix to treat the troubles. In their study of 87 women from 35 to 60 years old, the investigators found that distinct mixes were typical of the different stages of a woman's reproductive life and that a certain mix that becomes much more common after menopause was typical in the women who had VVA symptoms.
All these distinct mixes have types of Lactobacillus in them, a genus of bacteria typical in yogurt cultures and over-the-counter probiotics. When levels of Lactobacillus bacteria are low, the vagina tends to be dry. But the article's authors think that using products like these with lactobacilli that aren't native to an individual woman's vagina might do more harm than good. Personalized probiotics may be needed to treat or prevent VVA.
The article, "Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy," will be published in the May print edition of Menopause.
Source: Menopause

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