Depression and anxiety may result from short-term digestive irritation early in life, a study of laboratory rats by researchers at the Stanford University School of Medicine has indicated.
The findings suggested that some human psychological conditions might be the result, rather than the cause, of gastrointestinal disorders such as irritable bowel syndrome."A lot of research has focused on understanding how the mind can influence the body," said Pankaj Pasricha, professor and chief of gastroenterology and hepatology.
"But this study suggests that it can be the other way around. Gastric irritation during the first few days of life may reset the brain into a permanently depressed state," added Pasricha.
To test their hypothesis, the researchers used a laboratory model of functional dyspepsia they had developed years earlier. They subjected 10-day-old laboratory rats to mild stomach irritation daily for six days.
The findings suggested that some human psychological conditions might be the result, rather than the cause, of gastrointestinal disorders such as irritable bowel syndrome."A lot of research has focused on understanding how the mind can influence the body," said Pankaj Pasricha, professor and chief of gastroenterology and hepatology.
"But this study suggests that it can be the other way around. Gastric irritation during the first few days of life may reset the brain into a permanently depressed state," added Pasricha.
To test their hypothesis, the researchers used a laboratory model of functional dyspepsia they had developed years earlier. They subjected 10-day-old laboratory rats to mild stomach irritation daily for six days.
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