Scientists from Ohio State University's Institute of Behavioral Medicine Research have discovered that a model of social stress can increase inflammation among brain cells, providing new insight into how the stress response in the brain affects inflammatory and behavioral responses.
The findings may also provide new targets for drugs treatments in the continuing struggle to curtail depression and anxiety.John Sheridan, professor of oral biology, and Jonathan Godbout, an assistant professor of molecular virology, immunology and medical genetics, turned to colonies of mice to make their discoveries.
Groups of mice living together quickly adopt a hierarchy ranging from dominant to subordinate. This vaguely political system controls the interaction among the animals.
Once these patterns had been established, the researchers then added an additional, highly aggressive mouse to the mix for a two-hour period each day to disrupt the social hierarchy.
The findings may also provide new targets for drugs treatments in the continuing struggle to curtail depression and anxiety.John Sheridan, professor of oral biology, and Jonathan Godbout, an assistant professor of molecular virology, immunology and medical genetics, turned to colonies of mice to make their discoveries.
Groups of mice living together quickly adopt a hierarchy ranging from dominant to subordinate. This vaguely political system controls the interaction among the animals.
Once these patterns had been established, the researchers then added an additional, highly aggressive mouse to the mix for a two-hour period each day to disrupt the social hierarchy.
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