A trio of genes linked to migraine headaches have been uncovered by researchers, reveals study.
Migraines are acutely debilitating headaches -- sometimes with an "aura", in which patients have the impression of seeing through frosted glass -- that strike up to 20 percent of the population.Scientists describe the condition, which is three to four times more common in women, as a brain disorder in which neurons, or brain cells S==, respond abnormally to stimuli. The precise cause it unknown, but inheritance is thought to play a significant role. To assess the genetic component, Markus Schuerks of Brigham and Women's Hospital in Boston coordinated an international sweep of genomes in 23,230 women, 5,122 of whom suffered from migraines. So-called genome-wide association studies compare differences between individuals across the approximately three billion pairs of basic molecular building blocks found in the human genetic code.
The study, published Sunday in the British journal Nature Genetics, is the largest to date of its kind. It found variations in three genes that showed up more frequently in migraine patients.
Two of them, known as PRDM16 and TRPM8, were specific to migraines, as opposed to other kinds of headaches.
TRPM8, in addition, was linked to migraines only in women. Earlier studies have shown that the same gene contains the genetic "blueprint" for a pain sensor, in both men and women.
The third suspect gene, LRP1, is involved in sensing the external world and in chemical pathways inside the brain.
Migraines are acutely debilitating headaches -- sometimes with an "aura", in which patients have the impression of seeing through frosted glass -- that strike up to 20 percent of the population.Scientists describe the condition, which is three to four times more common in women, as a brain disorder in which neurons, or brain cells S==, respond abnormally to stimuli. The precise cause it unknown, but inheritance is thought to play a significant role. To assess the genetic component, Markus Schuerks of Brigham and Women's Hospital in Boston coordinated an international sweep of genomes in 23,230 women, 5,122 of whom suffered from migraines. So-called genome-wide association studies compare differences between individuals across the approximately three billion pairs of basic molecular building blocks found in the human genetic code.
The study, published Sunday in the British journal Nature Genetics, is the largest to date of its kind. It found variations in three genes that showed up more frequently in migraine patients.
Two of them, known as PRDM16 and TRPM8, were specific to migraines, as opposed to other kinds of headaches.
TRPM8, in addition, was linked to migraines only in women. Earlier studies have shown that the same gene contains the genetic "blueprint" for a pain sensor, in both men and women.
The third suspect gene, LRP1, is involved in sensing the external world and in chemical pathways inside the brain.
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