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Thursday 18 July 2013

Inst. of Wood Science confirms diabetes control with kokum on mice, plans trials on humans

Institute of Wood Science and Technology, Chemistry of Forest Produce Division, Bengaluru which comes under the umbrella of the Indian Council of Forest Research Education (ICFRE) has now proven data that Garcinia indica commonly  referred to as kokum is efficacious in controlling diabetes following its extensive animal study. The Institute is now in talks with the Union government funding agencies for its next round of research aid to take the study forward. In its next phase of research, the Institute is gearing up for the toxicity assessment and clinical trials on humans.
The research which was funded by its parent body ICFRE which is part of the Ministry of Environment & Forests had the Institute of Wood Science and Technology to rope in the Al Ameen Pharmacy College and the PES College of Pharmacy in Bengaluru to conduct the study at its laboratories.
Kokum or the Goa butter tree, also known as Mangosteen is used as an edible fat because it is nutritive and antiseptic.
In the animal study, kokum rind extract was used with different sequential extracts. The rind has antioxidant property.
For the initial study on mice, the researchers adopted the Alloxan model which is a diabetes inducing drug and then controlled with a another medication after which  Garcinia indica or kokum was administered. In an effort to validate further, the researchers also adopted the Streptozotocin model to verify and provide additional evidence on the reduction of sugar levels in mice with kokum fruit rind extract against the Alloxan model. Both the models demonstrated excellent results, Chandrashekar BS scientist, Chemistry of Forest Produce Division, Institute of Wood Science and Technology who led the study told Pharmabiz.
“We investigated whether Garcinia indica has anti-diabetic effect in type II diabetes mellitus. The type II diabetes was induced by STZ and Nicotinamide. Streptozotocin is well known to inducing high blood sugar or hyperglycemia. There were three stages of drug administration ranging from acute to chronic over a period of a week, 14 days and 21 days. The 21 day induced drug indicated a 50 percent in reduction of sugar levels which was a clear indication on the efficacy of kokum,” he added.
Now the Institute of Wood Science and Technology has completed the basic research and have the required data on the positive effect of Garcinia indica which is  used as antioxidant, anti-hyperlipidemic and anticancer. “But the anti diabetic activity of Garcinia indica had not been studied. Hence the present study was to evaluate anti diabetic activity of Garcinia indica. Now the government of India should allocate more funds for such research findings that would only benefit the scores of diabetes patients in the county who are on oral diabetic formulations and insulin. There is need to provide an economical and easily accessible source for diabetic control. Kokum is popular in the coastal areas especially the west coast where is used a coolant beverage and recommended as a digestive too,” said Chandrashekar.

Source:Pharmabiz

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