This technology would enable better clinical diagnosis at an earlier stage and may provide insight into new therapeutic targets, said Rachel Ostroff, Ph.D., clinical research director of Somalogic Inc.
"Currently these cancers are detected at an advanced stage, where the possibility of cure is minimal," said Ostroff. "Detection of these aggressive cancers at an earlier stage would identify patients for early treatment, which may improve their survival and quality of life."
Ostroff presented results of this ongoing study at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development.
Discovered about 20 years ago, aptamers are nucleic acid molecules that bind to specific proteins. SomaLogic has developed the next generation of aptamers, SOMAmers (Slow Off-rate Modified Aptamers), which have superior affinity and specificity. SOMAmers enable a highly multiplexed proteomic platform used for simultaneous identification and quantification of target proteins in complex biological samples.
The goal of this study was to determine if this proteomics technology could identify blood-based biomarkers for pancreatic cancer or mesothelioma in people diagnosed, but not yet treated, for cancer.
Participants in the control group had symptoms that resembled these cancers, but were benign (i.e. pancreatitis or lung fibrosis).
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